Many of the names are as familiar as Hendrix and Townshend, but there are others you might not know, like Link Wray and Scotty Moore.
Who are your picks, and why? Send them to us ahead of Wednesday's show. Post a comment here, on Facebook or tweet them to us @hereandnow. We'll talk with Alan Light, a Rolling Stone contributor who wrote some of the profiles in the special issue.
In the meantime, can you name each of the guitarists in this audio montage? If you get stumped, you can see the answers here.
Wednesday's show: The Greatest Guitarists Of All Time
This segment aired on October 9, 2012. The audio for this segment is not available.