Guthrie Pitches Orioles Past Red Sox 6-2

Jeremy Guthrie allowed two runs in seven innings in an effort that belied his title as the losingest pitcher in the majors, and the Baltimore Orioles beat Boston 6-2 Tuesday night to end a seven-game losing streak against the Red Sox.

Derrek Lee and Mark Reynolds hit successive homers in the eighth inning off Alfredo Aceves to turn a shaky one-run lead into a more comfortable cushion for the Orioles, who lost their previous seven games against Boston this season by a combined score of 61-32.

Guthrie (4-13) gave up eight hits, struck out four and walked one. The right-hander was 1-6 in his previous 10 starts and had lost seven straight decisions against Boston since May 13, 2008.

Jim Johnson worked the final two innings for his first save. Orioles closer Kevin Gregg was unavailable because he was serving a three-game suspension for his involvement in a bench-clearing melee at Fenway Park on July 8.

The Red Sox lost for only the third time in 16 games despite getting a home run from Jarrod Saltalamacchia, his second in two nights. Josh Reddick had three hits and scored a run.

Boston's Dustin Pedroia beat out a grounder in the first inning to extend his hitting streak to 17 games, tying a career high set in 2008. He has also reached base in 29 consecutive games, which also matches his career-best run.

After lasting only four innings against Baltimore on July 10 in his major league debut, Kyle Weiland displayed far more poise in the encore. The right-hander allowed three runs and six hits in six innings but was outdone by Guthrie, who yielded 12 runs over 10 innings in his prior two starts.

Guthrie faced a lineup without Boston's leading home run hitter, David Ortiz, who is also serving a three-game suspension stemming from the fight in the previous series between the teams.

The game drew a crowd of 32,314, many of whom were cheering for the Red Sox. It's a common occurrence at Camden Yards when Boston comes to town, although Orioles manager Buck Showalter wasn't complaining.

"Well, we had a lot of Red Sox people here last night," he said before the game. "We'll take their admission and put it towards keeping our players. Thank you very much."

Baltimore went up 2-0 in the second inning when Adam Jones and Matt Wieters singled, Reynolds hit an RBI double and Nolan Reimold followed with a run-scoring grounder.

Weiland retired the first two batters in the third before Nick Markakis drew a walk, Jones singled and Wieters bounced an RBI single off the glove of first baseman Adrian Gonzalez.

Saltalamacchia made it 3-2 in the fifth with a drive over the right-field scoreboard after Reddick hit a leadoff double. Boston then put runners on the corners with two outs before Pedroia grounded out.

The Red Sox didn't get another runner past first base the rest of the way.

Lee hit a two-run homer with two outs in the eighth and Reynolds followed with his team-high 21st home run.