Chris Parmelee hit a game-ending homer in the ninth inning and the Minnesota Twins overcame David Ortiz's big night to beat the Boston Red Sox 8-6 on Tuesday.
Ortiz went 4 for 5 with two homers and four RBIs, but it wasn't enough.
Kurt Suzuki singled with two outs off reliever Andrew Miller (1-1) before Parmelee lined an 0-1 pitch into the right-field seats for his first two RBIs of the season.
Eduardo Nunez homered and Brian Dozier had two RBIs in a five-run second for Minnesota.
Ortiz hit solo homers in the first and fourth and is tied with Jim Rice on the Red Sox list with 382. It was the 42nd multihomer game for Big Papi, who began his career with the Twins.
Ortiz added an RBI single in the sixth and another one in the seventh that made it 6-5.
Glen Perkins (1-0) pitched the ninth, striking out Ortiz and Mike Napoli to strand Shane Victorino at first base.
Boston scored three times in the seventh and tied the score at 6 after reliever Matt Guerrier walked pinch-hitter Jonny Gomes with the bases loaded.
Caleb Thielbar came on to strike out former Twins catcher A.J. Pierzynski with the bases loaded to stop the rally.
Leading 6-3, Minnesota left the bases loaded in the sixth. It also stranded runners on second and third in the third and fifth.
Red Sox starter Jake Peavy allowed six runs on nine hits in 4 1-3 innings and failed to complete at least five innings for the first time in 18 starts with Boston.
Ricky Nolasco allowed three runs and struck out six in six innings for the Twins. Joe Mauer and Suzuki each had an RBI single.
The Minnesota Wild goal horn blared every time the Twins scored a run as the Wild played the Chicago Blackhawks in the NHL playoffs a few miles down the road in St. Paul.
As soon as Parmelee touched home plate, the horn blared even louder as Parmelee's teammates mobbed him all the way to the dugout.
A victory would have given the Red Sox their first three-game winning streak of the season.
Boston manager John Farrell originally listed Peavy as Wednesday's starter, but said he intended to start Peavy on Tuesday all along and "screwed up" when announcing the probables for this series.