Wade Miley's dominant performance against the Los Angeles Angels was wasted on one fat pitch Boston Red Sox closer Koji Uehara threw to Mike Trout.
The reigning AL MVP hit a two-out walkoff home run in the ninth inning, sending the Red Sox to a 1-0 loss Friday night after seven-plus innings of one-hit ball by Miley.
Trout, the reigning AL MVP, drove Uehara's 0-1 pitch way over the fence in left-center for his league-leading 27th homer.
"I needed to be ready in that situation," Uehara (2-4) said through a translator. "I was trying to go a little bit more outside on that pitch. I knew that I had a good record against him, but he had a good at-bat against me today."
Trout picked up right where the left off from Tuesday's All-Star Game, which began with his home run against major league ERA leader Zack Greinke. It earned him his second straight All-Star MVP award.
"It's been crazy, for sure. One of those weeks I'm definitely going to remember," Trout said. "It's been fun, though. It's just why we play the game, to have fun and try to win ballgames.
"I was just trying to keep my approach and just control my emotions, not try to hit a home run there," he added. "If I went up there trying to hit it out, it probably wouldn't have happened. But I trusted my approach. I'm just trying to get out on the right foot in the second half. We just kept battling and came out with the `W."'
Miley retired his first 16 batters, retiring Trout on a grounder in the first and striking him out in the fourth before walking Chris Iannetta with one out in the sixth.
Kole Calhoun broke up the no-hit bit in the seventh with a leadoff double over the head of center fielder Mookie Betts that hit the fence on the fly. It came on the left-hander's first pitch of the inning and 85th of the game.
"That was a well-played game, and unfortunately, we came up on the wrong end of a 1-0 score," manager John Farrell said. "But Wade was outstanding. He was aggressive and he threw a lot of strikes. There were some at-bats where he got behind in the count, but he found a way back in to salvage the at-bat and made a big pitch a couple of times on 3-2 counts."
The Angels, who scored 10 or more runs four times during their nine-game road trip leading into the break - are hitless in their last 30 at-bats at home with runners in scoring position.
"That's a play Xander doesn't make a year ago," Farrell said. "He ranges far to his right and gets a speedy runner by a good step to preserve a scoreless tie to end the seventh inning. That's an outstanding major league play."
Farrell pulled Miley after he issued a leadoff walk to David Freese with his 101st pitch. Miley, who came in with a 4.80 ERA, struck out six in his first start since giving up six runs through 5 1-3 innings in a 5-3 home loss to the Yankees last Sunday.
Angels lefty C.J. Wilson scattered five hits and three walks over eight innings while striking out four. It was the third time in his last five starts that the Angels didn't score while he was in the game.
Joe Smith (2-1) pitched a perfect ninth.
Red Sox second baseman Dustin Pedroia was 0 for 4 in his first game off the disabled list. He had been sidelined since June 25 because of a strained right hamstring.
Red Sox: RHP Clay Buchholz, seeking a second opinion on the strained flexor muscle in his forearm that has sidelined him since July 11, is planning on seeing Dr. James Andrews in Pensacola, Florida on Wednesday. His turn in the rotation next Tuesday against Houston will be taken by rookie LHP Brian Johnson, who will make his big league debut following his promotion last Saturday from Triple-A Pawtucket.
Angels: RHP Huston Street, sidelined by a groin strain that occurred on his final pitch of in a save at Colorado on July 8, threw a bullpen session and is expected to be eligible to close again Saturday. He needs one save to become the 27th player with at least 300.
Red Sox: RHP Rick Porcello (4-9) will be pitching on nine days' rest against the Angels, who beat him 12-5 on May 22 in Boston.
Angels: RHP Garrett Richards (9-6) will pitch on eight days' rest.