Advertisement6 Things To Know If You're Immunocompromised And Considering A 3rd ShotAugust 14, 2021Carmel WrothAllison AubreyWill StoneJane GreenhalghfacebookEmailHaving a compromised immune system puts you at higher risk of severe illness and death from COVID-19. Studies show that the initial vaccine doses are less effective for people with weakened immune systems. A third shot can boost protection. (Boston Globe via Getty Images)