In 2019, then-U.S. Labor Secretary Alexander Acosta, appointed by Trump, abruptly resigned. According to the Justice Department, Acosta played a "pivotal" role while working as a U.S. attorney in 2008, negotiating a deal for Epstein that helped him avoid federal sex-trafficking charges. Acosta denied any wrongdoing. A DOJ probe later concluded that Acosta used "poor judgment" in the case.

In November 2021, Jes Staley, then head of U.K.-based Barclays Bank, resigned after it was revealed that he maintained close ties to Epstein after Epstein's 2008 conviction for sex crimes. In a May 2023 report, British officials concluded Staley acted "recklessly and with a lack of integrity" while misleading regulators about his friendship with Epstein. Staley has denied any wrongdoing.
In February 2022, Prince Andrew reached a settlement with Giuffre, saying in court documents that he "regrets his association with Epstein" and agreeing to make a "substantial donation to Ms. Giuffre's charity in support of victims' rights," according to a document filed by David Boies, an attorney for Giuffre.
In May 2023, Deutsche Bank agreed to pay $75 million to settle claims by Epstein's victims that the bank was liable for "supporting, facilitating, and otherwise providing the most critical service for the Jeffrey Epstein sex trafficking organization." The settlement included no admission of wrongdoing by Deutsche Bank.
In May 2023, attorneys for JPMorgan claimed in legal filings that government officials in the U.S. Virgin Islands, where Epstein maintained a home, "knew of and facilitated Epstein's crimes." However, the bank later agreed to pay $75 million to the Virgin Islands government to settle claims linked to Epstein's activity.
In June 2023, JPMorgan agreed to pay roughly $290 million into a settlement fund for victims, after serving for more than 15 years as Epstein's go-to bank. JPMorgan has denied any wrongdoing. "We all now understand that Epstein's behavior was monstrous," bank officials said in a statement sent to NPR.