After his mother died, Ed Zine developed severe obsessive compulsive disorder: He believed that he could "rewind" time by literally walking backwards each step he walked forward, that he could stop the future from happening by not throwing objects away. The condition ended up trapping him in a fetid basement for two years. How Ed learned to manage his condition is the subject of the book "Life in Rewind". We speak with both Ed Zine and Doctor Michael Jenike.

Interest groups have already started to gear up to fill the seat to be vacated by Justice David Souter. The vacancy gives President Obama his first chance to appoint a Supreme Court Justice. We'll speak with Jonathan Turley, professor of public interest law at George Washington University.

The 135th running of the Kentucky Derby is Saturday. Joe Drape of the New York Times joins us to preview the race.

To mark Barbie's 50th birthday, Mattel has opened its first store dedicated to the doll. It's in Shanghai China. The BBC's Chris Hogg took a tour.

Listeners weigh in on some recent stories--- we recently learned about Sharia banking, the relationship between drug companies and doctors and "Britain's Got Talent" instant celebrity Susan Boyle.

Synesthesia is a rare neurological condition that causes senses to conflate --- for example some 'synesthetes' see colors when they hear music or taste certain foods. We speak with Sean Day, who has synesthesia and is President of the American Synesthesia Association. We also hear from neurologist Dr. Richard Cytowic, who co-authored the book "Wednesday is Indigo Blue: Discovering the Brain of Synesthesia."